ea0016p517 | Obesity | ECE2008
Slawik Marc
, Jitrapakdee Sarawut
, Atherton Helen
, Hadaschick Dirk
, Kimber Wendy L
, Considine Robert
, Wallace John C
, Sethi Jaswinder K
, O'Rahilly Stephen
, Griffin Julian L
, Vidal-Puig Antonio
To maintain a proper lipid composition of cellular membranes is fundamental for cell viability and intracellular signalling. Therefore we hypothesised the existence of membrane quality control homeostatic mechanisms. Previously, we have shown that Pyruvate Carboxylase (PC), an enzyme involved in de novo lipogenesis and fuel partitioning, is a target of PPARĪ³ and that PC level is decreased in PPARĪ³ KO and obese insulin resistant mouse models. Here, we used RNAi...